CYP Design

providing better, faster and more convenient decision-making tools for drug discovery

CYPDESIGN is dedicated to supporting your drug research and development needs by offering you stabilised, highly active cytochrome P450 (CYP) enzyme products. These products are presented in our unique Sacchrosomes™ and are stable at room temperature. This provides significant cost advantages as our products do not need to be shipped with dry-ice, or kept in cold storage before use, and they will provide you with greater convenience due to their stability at room temperature. 

CYPDESIGN's products will satisfy your requirements for quality in early stage testing for new drug discovery. Our products are more active and more stable, easier to handle and more convenient to use than other commercially-available CYPs. 

We also offer reliable contract research services in metabolism and toxicity testing and in biocatalysis.

our technology

CYP Design's CEO, Bill Primrose, explains the unique features of the company's CYP stabilisation technology, in a video made to support the Start-Up of the Year Award from Medilink East Midlands in June 2014

product shot

new technology, new products

CYPDESIGN is building on the technological breakthroughs of its founder, Professor Bob Chaudhuri of De Montfort University, in the expression and stabilisation of the key family of human liver enzymes, cytochrome P450s (CYPs), responsible for the metabolism of chemicals in the body, including pharmaceuticals.

CYPDESIGN has developed a successful generic expression system for the production of recombinant CYPs in yeast, insect and mammalian cells. We have the ability to clone and produce a CYP from any organism (insect, parasite, fungi, plant, etc).

Our expression of human CYPs in yeast results in the production of highly active enzyme preparations presented in the form of Sacchrosomes™ (microsomes), our unique membrane system which brings together all the components necessary for activity in a convenient and highly reproducible way. 

Significantly, we have developed a unique stabilisation process that allows our Sacchrosomes™ to be despatched, stored and maintained at room temperature, greatly increasing their convenience to the end user.

View Products

more about stabilisation

CYPDESIGN has developed a unique stabilisation process that allows CYPs, which are ordinarily extremely labile at temperatures other than -80ºC, to be maintained at room temperature, greatly increasing their convenience for the end-user. They can thus be shipped and stored without the need for a cold chain.

Significantly, for the end user, not only do our Sacchrosomes™ make for ease of use, but in use the researcher isn't constrained to work within a particular timeframe.

the CYP options available to our customers

We can supply all of the major human drug metabolising CYPs, provided as dried down films, ready for reconstitution and immediate use. Shipped without the need for a cold chain, and with no need for low temperature storage, these are ready to use "off the shelf". And there is no need to pipette viscous, heterogeneous solutions.

Arrayed into the format of your choice, whether vials, 96- or 384-well microtitre plates, exact amounts of each CYP are aliquotted into the wells of a microtitre plate.

All CYP products contain NADPH-dependent P450 reductase, and cytochrome b5 where necessary, and are presented as lyophilised films ready for immediate reconstitution and use in your assays.

Sacchrosomes™ performance

Yeast microsomes are more similar to the mammalian system than those from insect cells. 

CYPDESIGN's yeast microsomes (presented in our unique Sacchrosomes™) reliably demonstrate that the yield and activity of human CYP enzymes in Sacchrosomes™ are at least comparable and often better than those from other suppliers who use insect cells or bacteria.

In the Comparative Performance section of this site you will find representative kinetic plots for nine different human CYPs, comparing the activities from CYPDESIGN's Sacchrosomes™ with those from a leading supplier's insect cell-expressed CYPs. More detailed comparisons are shown in the product data sheets accompanying each individual CYP Sacchrosome™.

technological breakthroughs

Bob_and_team.jpg

Professor Bob Chaudhuri, and team

CYPDESIGN has developed a unique stabilisation process that allows CYPs to be maintained at room temperature, greatly increasing their convenience for the end-user. Thus they can be shipped and stored without the need for a cold chain.

CYPDESIGN is building on the technological breakthroughs of its founder, Professor Bob Chaudhuri of De Montfort University, in the expression and stabilisation of the key family of human liver enzymes, cytochrome P450s (CYPs), responsible for the metabolism of chemicals in the body, including pharmaceuticals.

Professor Chaudhuri has developed proprietary technology for the expression of recombinant human CYPs, which are more active and more stable, cheaper to produce, and more convenient to use than other commercially-available CYPs. 

CYPDESIGN's successful generic expression system allows for the production of recombinant CYPs in yeast, insect and mammalian cells. We have the ability to clone and produce a CYP from any organism (insect, parasite, fungi, plant, etc).

Our expression of human CYPs in yeast results in the production of highly active enzyme preparations presented in the form of Sacchrosomes™ (microsomes), a unique membrane system which brings together all the components necessary for activity in a convenient and highly reproducible way.

CYPDESIGN has also developed a unique stabilisation process that allows CYPs, which are ordinarily extremely labile at temperatures other than -80ºC, to be maintained at room temperature, greatly increasing their convenience for the end-user. They can thus be shipped and stored without the need for a cold chain.

CYPDESIGN's team also has considerable expertise in CYP biology and chemistry, providing the basis for new products and services, including metabolism and toxicity testing services, reagents for biocatalysis, and the potential for developing new cancer therapeutics.

our team

CYPDESIGN make drug discovery better by providing products that have a significant impact on the timescales and costs involved in the early stages of drug discovery.

Our team is dedicated to seeing better, faster and more convenient decision-making tools available for drug discovery. Applying the technology that world-renowned expert Professor Chaudhuri and his team have been developing in the field of human CYP enzyme expression and stabilisation.

news & development

career opportunities

CYPDESIGN is a young and vibrant biotech company headquartered in Leicester, which is developing new products and services for the global drug discovery industry. The company has developed proprietary technology for the expression of human cytochrome P450 enzymes (CYPs) in yeast, and their subsequent stabilisation, allowing transport and storage at ambient temperature. 

We expect to see significant growth through a milestone driven strategy and global diversification. As we expand, we will bring on a plethora of exceptional talent to help us further extend our manufacturing and marketing capabilities. These talented people will help us to diversify our product lines, enabling us to become the global leader for CYP-based products and services.

CYPDESIGN currently has a vacancy for an experienced molecular cell biologist to be appointed as a Senior Scientist (position CDL-03).  The position is available immediately.

PLEASE NOTE THAT THE DEADLINE FOR APPLICATIONS FOR THIS POSITION HAS NOW PASSED

our contact information

get in touch with us

Contact us via any of the following methods, or feel free to get in touch via this email form.

Leicester Head Office:

CYP Design Limited
Innovation Centre
49 Oxford Street
Leicester
LE1 5XY
United Kingdom

Sales Office & Information:

38 Greville Road
Cambridge
CB1 3QL

Phone: 01223 247468
Email: info@cypdesign.co.uk