All major human drug metabolising CYPs are available, with exact amounts of each CYP aliquotted into wells of a microtitre plate. CYPs are provided as dried down films, ready for reconstitution and immediate use. There's no need to pipette viscous, heterogeneous solutions.
Arrayed into the format of your choice, whether vials, 96- or 384-well microtitre plates, there's no need for low temperature shipping or storage. Our products are ready to use off the shelf.
All CYP products contain NADPH-dependent P450 reductase, and cytochrome b5 where necessary, and are presented as lyophilised films ready for immediate reconstitution and use in your assays.
Yeast microsomes are more similar to the mammalian system than those from insect cells.
CYPDESIGN has demonstrated that the yield and activity of our human CYP enzymes in Sacchrosomesâ¢ (microsomes) are at least comparable and often better than those from other suppliers who use insect cells or bacteria.
Representative kinetic plots for each of nine different human CYPs are shown under CYPs & Formats, comparing the activities from CYPDESIGN's Sacchrosomesâ¢ with those from a leading supplier's insect cell-expressed CYPs. More detailed comparisons are available in product data sheets accompanying each individual Sacchrosomeâ¢ CYP. Please use the Contact Form to make a request.
CYPDESIGN has developed a unique stabilisation process that allows CYPs, which are ordinarily extremely labile at temperatures other than -80ÂºC, to be maintained at room temperature, greatly increasing their convenience for the end-user. They can thus be shipped and stored without the need for a cold chain.
Protocols are available for all of our CYP products. These will be made available on this web site, but please contact us for information in the mean time.
CYPDESIGN is pleased to announce that it has completed a Â£325k seed funding round led by Gask Consulting under the Enterprise Investment Scheme (SEIS). As part of the EIS round, Mercia Fund Management also followed its earlier SEIS investment.
CYPDESIGN is delighted to announce that it has been given the Start-Up of the Year award at the Medilink East Midlands Innovation Day Business Awards in Leicester on 11th June 2014.
CYPDESIGN has been awarded a grant by the government-backed Technology Strategy Board - the UK's innovation agency - to help support the development of new products and services, based on cytochrome P450s (CYPs).
Full Press Release available
CYPDESIGN is seeking to purchase or rent a lyophiliser with temperature-controlled shelves to develop its in-house production process for the manufacture of stabilised, dry films of sensitive membrane-bound enzymes. A research laboratory-scale instrument is required at this stage.
CYPDESIGN has been awarded funding by the UK Defence Science and Technology Laboratory's (Dstl) Centre for Defence Enterprise (CDE) for research designed to validate an automated platform for the discovery of safe, effective, broad-spectrum anti-bacterial compounds.
Full Press Release Available:
CYPDESIGN is pleased to announce that it has completed a seed funding round led by Mercia Fund Management Ltd (MFM) under the Seed Enterprise Investment Scheme (SEIS). As part of the SEIS round, the founders Prof Bob Chaudhuri, Dr Bill Primrose and Dr Paul Rodgers have been joined by Mr David Gask, a leading entrepreneur, as Chairman of the Board.
Full Press Release Available:-
CYPDESIGN presented its technology in the Innovation Zone of the ELRIG DD Conference in Manchester Central. We exhibited our products for metabolism and toxicity testing in Booth IZ4.
CYPDESIGN published an article in 'Industrial Pharmacy' entitled "Stable Cytochorme P450 Enzymes for Toxicity and Metabolism Testing". See Industrial Pharmacy, June 2013, Issue 38, pages 4 - 7
CYPDESIGN presented in the 'Platform & Diagnostics' Session of the 10th Anniversary EPIC Biotechnology Conference at the King's Fund in London on Thursday 6th June 2013.
CYPDESIGN was a finalist in the Royal Society of Chemistry's Emerging Technologies Competition, held in the Chemistry Centre, Piccadilly, London on Wednesday 5th June 2013.
CYPDESIGN attended BioWales 2013 at the Wales Millennium Centre, Cardiff
CYPDESIGN exhibited its unique stabilised cytochrome P450 products in the New Technology Showcase at the ELRIG Research and Innovation meeting in Telford